細胞膜標志物
細胞膜是細胞的外部結構,是防止細胞外物質自由進入細胞的屏障,它不僅為細胞提供物理保護,還負責控制物質的進出、細胞間通訊以及許多其他重要功能。細胞膜主要由磷脂雙分子層構成,其中包含蛋白質、膽固醇和糖分子。磷脂雙分子層由兩個磷脂分子層組成,疏水性的脂肪酸尾部朝內,親水性的頭部朝外形成一個半透膜。
細胞間黏附分子(Cell Adhesion Molecules,CAMs)、受體酪氨酸激酶(Receptor Tyrosine Kinases,RTKs)和離子通道蛋白等細胞膜標志物在細胞功能和信號轉導中起關鍵作用。CAMs是一類膜蛋白,具有細胞黏附、細胞間通信和信號傳導的功能。RTKs是一類跨膜受體蛋白,能夠通過受體激酶活化細胞內的信號通路。常見的RTKs包括表皮生長因子受體(EGFR)、血小板源性生長因子受體(PDGFR)和神經生長因子受體(NGFR)等。離子通道蛋白是一類位于細胞膜上的蛋白質,它們形成了穿越細胞膜的通道,能夠調節(jié)細胞內外離子的平衡。常見的離子通道蛋白包括鈉、鉀和鈣通道等,它們對于維持細胞的電生理特性和信號轉導至關重要,并且參與神經傳導、肌肉收縮和心臟節(jié)律等生理過程。
ATP1A1編碼的蛋白屬于p型陽離子轉運ATP酶家族和Na+/K+ - ATP酶亞家族。ATP1A1是活性酶的催化成分,可催化ATP的水解,并通過質膜交換鈉離子和鉀離子。這一作用產生了鈉離子和鉀離子的電化學梯度,為各種營養(yǎng)物質的主動運輸提供能量。
圖1 ATP1A1抗體免疫組化結果示意圖
(商品貨號:K111558P)
CDH3基因位于16號染色體長臂區(qū)域的一個基因簇中,編碼鈣粘蛋白超家族中的一種經典鈣粘蛋白。鈣粘蛋白是一種依賴鈣的細胞粘附蛋白,它們在連接細胞時優(yōu)先以親同性的方式相互作用,鈣粘蛋白可能有助于異質細胞類型的分選。
圖3 CDH3抗體免疫組化結果示意圖
(商品貨號:K111121P)
已有一些蛋白被鑒定可用作細胞膜標志物(見表1)。
表 1 細胞膜標志物
相關產品
產品貨號 |
產品名稱 |
K109982P |
Anti-ATP1A1 Polyclonal Antibody |
K110469P |
Anti-ATP1A1 Polyclonal Antibody |
K111558P |
Anti-ATP1A1 Polyclonal Antibody |
K005524P |
Anti-ATP1A1 Polyclonal Antibody |
K007644P |
Anti-ATP1A1 Polyclonal Antibody |
K111556P |
Anti-ATP1A2 Polyclonal Antibody |
K004215P |
Anti-ATP1B1 Polyclonal Antibody |
K106561P |
Anti-CADH1 Polyclonal Antibody |
K010592M |
Anti-CD26(APC) Monoclonal Antibody |
K010787M |
Anti-CD26(FITC) Monoclonal Antibody |
K011048M |
Anti-CD26(PE) Monoclonal Antibody |
K115158P |
Anti-CDH1 Polyclonal Antibody |
K002267P |
Anti-CDH1 Polyclonal Antibody |
K111121P |
Anti-CDH3 Polyclonal Antibody |
K008218P |
Anti-CDH3 Polyclonal Antibody |
K111282P |
Anti-CDH5 Polyclonal Antibody |
K001742P |
Anti-CDH5 Polyclonal Antibody |
K106786P |
Anti-DPP4 Polyclonal Antibody |
K002791P |
Anti-DPP4 Polyclonal Antibody |
K011355P |
Anti-E-Cadherin Polyclonal Antibody |
K000137M |
Anti-EGFR Monoclonal Antibody |
K000139M |
Anti-EGFR Monoclonal Antibody |
K000140M |
Anti-EGFR Monoclonal Antibody |
K106563P |
Anti-EGFR Polyclonal Antibody |
K112830P |
Anti-EGFR Polyclonal Antibody |
K112831P |
Anti-EGFR Polyclonal Antibody |
K002208P |
Anti-EGFR Polyclonal Antibody |
K002209P |
Anti-EGFR Polyclonal Antibody |
K002298P |
Anti-EGFR Polyclonal Antibody |
K002300P |
Anti-EGFR Polyclonal Antibody |
K009458P |
Anti-EGFR Polyclonal Antibody |
K009564P |
Anti-EGFRvII Polyclonal Antibody |
K009589P |
Anti-phospho-CTNNB1(Ser33+37) Polyclonal Antibody |
K006171P |
Anti-Phospho-EGFR-T669 Polyclonal Antibody |
K006212P |
Anti-Phospho-EGFR-Y1068 Polyclonal Antibody |
K006173P |
Anti-Phospho-EGFR-Y1148 Polyclonal Antibody |
K006169P |
Anti-Phospho-EGFR-Y845 Polyclonal Antibody |
K006172P |
Anti-Phospho-EGFR-Y992 Polyclonal Antibody |
K006172P |
Anti-Phospho-EGFR-Y992 Polyclonal Antibody |