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北京索萊寶科技有限公司
產(chǎn)品展廳
Anti-CD8 Polyclonal Antibody
  • 品牌:Solarbio
  • 產(chǎn)地:北京
  • 貨號:K106402P
  • 發(fā)布日期: 2019-05-13
  • 更新日期: 2025-08-29
產(chǎn)品詳請
產(chǎn)地 北京
品牌 Solarbio
保存條件 Store at -20°C. Avoid freeze / thaw cycles.
貨號 K106402P
應(yīng)用范圍 WB
CAS編號
抗體名 Anti-CD8 Polyclonal Antibody
克隆性 Polyclonal Antibody
靶點 KCTD17
適應(yīng)物種 Mouse
形態(tài)
宿主 Rabbit
亞型 IgG
標(biāo)識物 CD8A;MAL;Leu2;p32;OKT8 T cell antigen
濃度 %
免疫原 A synthetic peptide of human CD8
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
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