| 英文名稱 | Anti-BAX Polyclonal Antibody |
|---|
| 宿主 | Rabbit |
|---|
| 別名 | Bcl2-L-4;Bax-protein;BAX_HUMAN;BAXA |
|---|
| 應(yīng)用 | IHC |
|---|
| 稀釋比例 | IHC 1:50-200. |
|---|
| 交叉反應(yīng) | Human |
|---|
| 蛋白分子量 | 21kDa |
|---|
| Gene ID | 581 |
|---|
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
|---|
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
|---|
| 純化方法 | Affinity purification |
|---|
| 亞型 | IgG |
|---|
| 免疫原 | A synthetic peptide of human BAX |
|---|
| 性狀 | 液體 |
|---|
| Public Immunogen Range | A synthetic peptide of human BAX |
|---|
| Swiss Prot | Q07812 |
|---|
| Subcellular Locations | Cytoplasm Cytoplasm Mitochondrion membrane Single-pass membrane protein |
|---|
| *類型 | Polyclonal Antibody |
|---|
| 背景資料 | Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.7 |
|---|
