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北京索萊寶科技有限公司
產(chǎn)品展廳
Anti-SMAD1 Polyclonal Antibody
  • 品牌:Solarbio
  • 產(chǎn)地:北京
  • 貨號:K107039P
  • 發(fā)布日期: 2019-05-13
  • 更新日期: 2025-08-22
產(chǎn)品詳請
產(chǎn)地 北京
品牌 Solarbio
保存條件 Store at -20°C. Avoid freeze / thaw cycles.
貨號 K107039P
應用范圍 IHC
CAS編號
抗體名 Anti-SMAD1 Polyclonal Antibody
克隆性 Polyclonal Antibody
靶點
適應物種 Human Mouse Cow
形態(tài)
宿主 Rabbit
亞型 IgG
標識物 BSP-1;BSP1;JV4-1;JV41;MADH1;MADR1;SMAD family member 1
濃度 %
免疫原 A synthetic peptide of human SMAD1
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
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